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KMID : 1134820190480050501
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 5 p.501 ~ p.508
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The Effects of Defatted Tenebrio molitor Larva Ferment Extract on CCl4-Induced Liver Damage in Mice
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Choi Ra-Yeong
Ham Ju-Ri
Ryu Hyo-Seon
Park Kyung-wuk
Kang Kyung-Yun
Lee Mi-Kyung
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Abstract
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This study investigated the effects of defatted Tenebrio molitor larva ferment extract (MWF) on CCl4-induced acute hepatotoxicity in mice. The ferment extract (500 mg/kg/d), non-ferment extract (500 mg/kg/d), and silymarin (positive control, 200 mg/kg/d) were orally administrated to mice for 3 days; then, CCl4 (2 mL/kg, 25% v/v in olive oil) was intraperitoneally injected on the third day. After 24 h of CCl4 injection, the mice were sacrificed to collect sera and liver tissue. CCl4 treatment caused an increase in the serum AST, ALT, IL-6, TNF-α, total bilirubin, and free fatty acid levels, and a decrease in the total cholesterol and HDL-cholesterol levels compared to the normal group. However, MWF significantly lowered the levels of serum IL-6 and free fatty acid, and tended to lower the ALT level compared to the control group. Histological analysis revealed that MWF attenuated liver injury caused by CCl4. Hepatic SOD activity was decreased in the control group compared with the normal group; however, MWF significantly reversed. Moreover, MWF significantly elevated hepatic GSH-Px and GST activities compared to the control group. This study demonstrated that MWF has antioxidative effects against CCl4-induced liver damage.
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KEYWORD
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carbon tetrachloride, liver, Tenebrio molitor fermentation
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